2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2740B
    Alcohol dehydrogenase, yeast 9031-72-5 98%
    Alcohol dehydrogenase, yeast is an alcohol dehydrogenase expressed in yeast. It can catalyze the conversion between ethanol and acetaldehyde, while also reducing NAD or NADP, and it plays a role in glycolysis and aerobic respiration.
    Alcohol dehydrogenase, yeast
  • HY-P2742A
    L-Ascorbate oxidase, Cucumber 9029-44-1 98%
    L-Ascorbate oxidase, Cucumber belongs to the family of oxidoreductases acting on diphenols and related substances as donor with oxygen as acceptor. L-Ascorbate oxidase, Cucumber catalyses the oxidation of L‐Ascorbate (HY-B0166) with oxygen to dehydroascorbate with the generation of water. L-Ascorbate oxidase, Cucumber can be used in baking processes and cereal‐based processes.
    L-Ascorbate oxidase, Cucumber
  • HY-P2742B
    Ascorbate oxidase, acremonium sp 9029-44-1 98%
    Ascorbate oxidase, acremonium sp is a member of the multicopper blue oxidase family and primarily exists in plants as a free enzyme in the cytoplasm or bound to the cell wall. Ascorbate oxidase, acremonium sp has a high activity in catalyzing the oxidation of ascorbic acid to dehydroascorbic acid, regulating various cellular processes related to plant growth, protection, and development. Ascorbate oxidase, acremonium sp can be used to detect hydrogen peroxide.
    Ascorbate oxidase, acremonium sp
  • HY-P2766A
    Trehalase, Microorganism 9025-52-9 98%
    Trehalase, Microorganism (EC 3.2.1.28) is a trehalase that can effectively degrade trehalose in some bacteria. Trehalase, Microorganism can be used as a marker for acute kidney injury caused by proximal tubule damage.
    Trehalase, Microorganism
  • HY-P2800A
    Diaphorase, clostridium sp. 9001-18-7 98%
    Diaphorase from Clostridium sp. is responsible for catalyzing the oxidation of NADH or NADPH and is involved in regulating cellular energy metabolism.
    Diaphorase, clostridium sp.
  • HY-P2802A
    α-Glucosidase, bacillus stearothermophilus 9001-42-7
    α-Glucosidase, bacillus stearothermophilus is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, bacillus stearothermophilus retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate.
    α-Glucosidase, bacillus stearothermophilus
  • HY-P2802B
    α-Glucosidase, rice 9001-42-7
    α-Glucosidase, rice is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, rice retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate.
    α-Glucosidase, rice
  • HY-P2807J
    L-Lactate Dehydrogenase (L-LDH), pig muscle 9001-60-9 98%
    L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC50 values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes.
    L-Lactate Dehydrogenase (L-LDH), pig muscle
  • HY-P2807K
    L-Lactate Dehydrogenase, bovine muscle 9001-60-9 98%
    L-Lactate Dehydrogenase, bovine muscle is an oxidoreductase. L-Lactate Dehydrogenase, bovine muscle catalyzes the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH.
    L-Lactate Dehydrogenase, bovine muscle
  • HY-P2818B
    Alkaline phosphatase, Chicken Intestine 9001-78-9 98%
    Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values.
    Alkaline phosphatase, Chicken Intestine
  • HY-P2819A
    Phosphofructokinase,Bacillus stearothermophilus 9001-80-3 98%
    Phosphofructokinase from Bacillus stearothermophilus is a key enzyme in sugar metabolism that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate during glycolysis. The enzyme's ability to bind fructose-6-phosphate can be inhibited by phosphoenolpyruvate (PEP), thereby regulating the rate of glycolysis. Phosphofructokinase from Bacillus stearothermophilus can be used for the measurement of fructose-6-phosphate levels.
    Phosphofructokinase,Bacillus stearothermophilus
  • HY-P2848A
    Cholesterol oxidase, rhodococcus sp 9028-76-6 98%
    Cholesterol oxidase, Rhodococcus sp. is a key enzyme in the cholesterol degradation process. It catalyzes the isomerization and oxidation of cholesterol mediated by the coenzyme FAD. Research indicates that cholesterol oxidase plays a crucial role in the pathogenicity of Mycobacterium tuberculosis by modulating the host macrophage immune response through inhibition of the Toll-like receptor 2 (TLR2) signaling pathway, thereby enhancing the survival of Mycobacterium tuberculosis. Cholesterol oxidase, from Rhodococcus sp., shows potential for research in the field of tuberculosis.
    Cholesterol oxidase, rhodococcus sp
  • HY-P2869C
    β1-3,4 Galactosidase 9031-11-2 98%
    β1-3,4 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3 and β1-4 linked galactose residues from oligosaccharides.
    β1-3,4 Galactosidase
  • HY-P2869D
    β1-3,6 Galactosidase, Xanthomonas manihotis 9031-11-2
    β1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal β1-3 and β1-6 linked galactose from complex carbohydrates and glycoproteins.
    β1-3,6 Galactosidase, Xanthomonas manihotis
  • HY-P2871A
    α1-3,6 Galactosidase, Xanthomonas manihotis 9025-35-8
    α1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of α1-3 and α1-6 linked galactose residues from oligosaccharides.
    α1-3,6 Galactosidase, Xanthomonas manihotis
  • HY-P2878A
    Phosphodiesterase l, Rattlesnake venom 9025-82-5 98%
    Phosphodiesterase l, Rattlesnake venom (PDE, Rattlesnake venom) is a non-selective phosphodiester bond hydrolase targeting phosphodiester bonds in oligonucleotides, catalyzing their hydrolysis into mononucleotides. Phosphodiesterase l, Rattlesnake venom cleaves phosphodiester linkages in DNA fragments digested by DNase I. Phosphodiesterase l, Rattlesnake venom is promising for research of nucleic acid structure and metabolism.
    Phosphodiesterase l, Rattlesnake venom
  • HY-P2879B
    Cholesterol esterase, Candida cylindracea 9026-00-0 98%
    Cholesterol esterase, Candida cylindracea is an enzyme located in the intestines that hydrolyzes cholesterol esters into cholesterol and free fatty acids. Also known as bile salt-stimulated lipase or carboxylester lipase, this enzyme facilitates cholesterol metabolism and absorption in the body. It can also be used as a biochemical reagent, and is employed in conjunction with cholesterol oxidase (HY-P2848) to measure cholesterol levels.
    Cholesterol esterase, Candida cylindracea
  • HY-P2879C
    Cholesterol esterase, schizophyllum commune 98%
    Cholesterol esterase, Schizophyllum commune is an enzyme that catalyzes the hydrolysis of cholesterol esters into free cholesterol and fatty acids, facilitating the absorption of cholesterol in the intestine. Cholesterol esterase, Schizophyllum commune can be used in combination with cholesterol oxidase to measure cholesterol content.
    Cholesterol esterase, schizophyllum commune
  • HY-P2888A
    Bilirubin oxidase, bacillus cereus 80619-01-8 98%
    Bilirubin oxidase, bacillus cereus is a multi-copper oxidase that catalyzes the oxidation of bilirubin into biliverdin, as well as other tetrapyrroles, phenols, and aryl diamines. Bilirubin oxidase, bacillus cereus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, bacillus cereus can be used to develop enzyme-based biosensors.
    Bilirubin oxidase, bacillus cereus
  • HY-P2888B
    Bilirubin oxidase, Magnaporthe oryzae 98%
    Bilirubin oxidase (BOD), Magnaporthe oryza is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase, Magnaporthe oryzae can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction.
    Bilirubin oxidase, Magnaporthe oryzae
Cat. No. Product Name / Synonyms Application Reactivity